BSAC Spring Conference 2020

Into Clinical Practice
- Bridging the gap between science, policy and effective antimicrobial use

A global overview of drug development and effective use through diagnostics, stewardship and shared learning

16-17 March 2020

Queen Elizabeth Conference Centre, Westminster, London

Global views, local problems: Innovative solutions to AMR and infection challenges

You will find links to the slide sets and poster presentations below.

Thursday 21st March

PLENARY SESSION: SPOTLIGHT ON AMR AND INFECTION MANAGEMENT

Shortages, stockouts and scarcity: The issues facing the security of antibiotic supply and the role for pharmaceutical companies

Dr Deidre Cogan, Writer/Editor, Access to Medicine Foundation

The link between social and economic deprivation and AMR - via Skype

Professor Ramanan Laxminarayan, Director and Senior Fellow, The Center for Disease Dynamics, Economics & Policy, Washington DC

Innovation and AMR

Professor Dilip Nathwani OBE, Director, Academic Health Sciences Partnership [AHSP] in Tayside, Consultant Physician and Honorary Professor of Infection, Ninewells Hospital and Medical School, Dundee

Tailoring stewardship to context: Drivers and patterns of antibiotic prescribing and consumption in rural China

Professor Helen Lambert, Professor of Medical Anthropology, Bristol Medical School, University of Bristol

KEYNOTE PRESENTATION: INAUGURAL JAC ANNUAL LECTURE

UK Initiatives to Reduce Inappropriate Antibiotic Prescribing

Professor Alan Johnson, Head of Surveillance in the Healthcare-Associated Infection & Antimicrobial Resistance (HCAI & AMR) Division of the National Infection Service, Public Health England

Parallel Session One: Here now and almost here! Infection management of the future

Update on sepsis

Dr Manu Shankar-Hari, NIHR Clinician Scientist, Reader in ICM, Guy’s and St Thomas’ Hospital and King’s College London

Bacteriophages - how significant will their impact be?

Professor Martha Clokie, Professor of Microbiology, University of Leicester

It all gone to worms - the role of odilorhabdins!

Dr Philippe Villain-Guillot, CEO, Nosopharm

Parallel Session Two: Diagnostics

Role of digital PCR in high accuracy measurement in infectious diseases

Dr Denise O’Sullivan, Science Leader, LGC

Inter-laboratory study comparing bacterial AMR predictions from WGS data

Dr Ronan Doyle, Research Associate, Great Ormond Street Hospital NHS Foundation Trust

Developing metrology to support antimicrobial discovery, validation and screening

Professor Max Ryadnov, Biometrology Leader, National Physical Laboratory

Standardisation of procalcitonin measurement

Dr Amandine Boeuf, Researcher, Laboratoire de Métrologie et d’Essai (LNE)

PLENARY SESSION: GARROD LECTURE

Garrod Lecture 2019: MDR efflux in Gram negative bacteria - how understanding resistance led to a new tool for drug discovery

Professor Laura Piddock, University of Birmingham and GARDP

Global Knowledge exchange - Antimicrobial Resistance and Stewardship

Professor Dilip Nathwani OBE, Director, Academic Health Sciences Partnership [AHSP] in Tayside, Consultant Physician and Honorary Professor of Infection, Ninewells Hospital and Medical School, Dundee

PLENARY SESSION: KEY INFLUENCING PAPERS: WHAT HAS INFLUENCED AND IMPACTED PRACTICE IN THE PAST FIVE YEARS?

Stewardship

Professor Dilip Nathwani OBE, Director, Academic Health Sciences Partnership [AHSP] in Tayside, Consultant Physician and Honorary Professor of Infection, Ninewells Hospital and Medical School, Dundee

Diagnostics

Dr Till Bachmann, Reader in Personalised Medicine in Infectious Diseases, Deputy Head of Division of Infection and Pathway Medicine, University of Edinburgh

Behaviour Change & AMR

Dr Esmita Charani, Senior Lead Pharmacist, Imperial College London

Friday 22nd March

PLENARY SESSION: CLINICAL LESSONS & FREE PAPERS SELECTED FROM ABSTRACTS

Managing self-limiting infections in community pharmacies: a cluster randomised controlled trial

Ms Eno Umoh, Public Health England

Ceftazidime/avibactam in paediatrics: Challenges and treatment outcomes

Mrs Frances Garraghan, Lead antimicrobial pharmacist, Manchester University Foundation Trust

Educating the workforce in AMR – too many gimmicks or coming up trumps?

Dr Angharad Davies, Clinical Associate Professor, Swansea University Medical School

Why do dentists prescribe antibiotics for adults with toothache or infection?

Mrs Wendy Thompson, University of Leeds

Structuring the Management of High-Risk Skin Infections: A Model Care Pathway

Dr Abid Hussain, University Hospitals of Birmingham NHS Foundation Trust

PLENARY SESSION: GENOMIC & MOLECULAR DIAGNOSTICS

Current and future directions for rapid AMR diagnostics

Dr Till Bachmann, Reader in Personalised Medicine in Infectious Diseases, Deputy Head of Division of Infection and Pathway Medicine, University of Edinburgh

MALDI-TOF-MS - beyond species ID

Dr Belén Rodriguez Sanchez, Hospital Gregorio Maranon, Madrid

AMR detection in the WGS era

Professor John Rossen, Medical Molecular Microbiologist, University of Groningen, The Netherlands

PLENARY SESSION: PUBLIC POLICY AND PUBLIC PERCEPTION - HOW IT IS SHAPED AND INFORMED

Antimicrobial resistance: how journalism can help

Ms Madlen Davies, Health and science editor, The Bureau of Investigative Journalism

Public perception of antimicrobials and AMR – how it is shaped and informed

Dr Laurie Denyer Willis, Research Fellow, London School of Hygiene and Tropical Medicine

Parallel Session One: New Initiatives to Support AMR Innovation

Public health driven R&D of antibiotics for priority drug resistant infections

Dr Seamus O'Brien, R&D Director, Global Antibiotic R&D Partnership (GARDP)

CARB-X: Building A Portfolio of New Antibiotics, Vaccines & Diagnostics with Open Science

Dr Richard Lawson, Director of the CARB-X Program Management Office

Swab and send – discovering new antimicrobials from natural products

Dr Adam Roberts, Senior lecturer, Liverpool School of tropical Medicine

Parallel Session two: Vaccines

What's new in conjugate vaccine development against infectious disease

Dr Viliam Pavliak, Senior Advisor, International Vaccine Institute

The global roadmap for STI vaccine development - state of the art review

Dr David McIntosh, Honorary Clinical Senior Lecturer, Imperial College London

The of Role of Vaccines in Preventing AMR

Dr Rajeka Lazarus, Consultant in Microbiology and Infectious Diseases, Bristol

PLENARY SESSION: DEBATE: CONSERVATION OF ANTIBIOTICS - RESERVING VERSUS HETEROGENICITY

Conservation of antibiotics is the ONLY way forward

Heterogencity: A little bit of everything will work wonders - cycling antibiotics is the future!

Poster abstracts

3

Investigating the effect of tobramycin dry powder inhaler on the eradication of Pseudomonas aeruginosa biofilms.

4

Linezolid- are we monitoring our patients when they are discharged

5

Audit to monitor the compliance of antibiotic prescribing and reviewing according to the trust guidelines at Acute Medical Unit at George Eliot Hospital NHS Foundation Trust

6

Antibiotic use in infants with acute watery diarrhoea in sub-Saharan Africa

9

Is the message getting through An update on public understanding of antibiotics from a nationwide household survey in England, 2017

13

Bovine TB tracheitis following introduction of a steroid inhaler

14

Galleria mellonella A novel tool for screening antimicrobial activity against the anaerobe Clostridium perfringens.

16

High levels of antibiotic prescribing in the community predict high numbers of bacterial infections requiring hospital admission

17

Does using gas plasma device change bacterial composition of diabetic foot ulcers and reduce the need for antibiotics

20

Antimicrobial resistance in lower respiratory tract infections of children a systematic review and meta-analysis

22

BSAC Bacteraemia Resistance Surveillance A five year review of non-susceptibility (2013-2017)

23

Epidemiology of Escherichia coli bacteraemia secondary to a urinary tract focus of infection an analysis of local antibiotic susceptibility

24

Non-medical Antimicrobial Stewardship Rounds

26

Knowledge, beliefs and practices on antibiotic use and resistance among a group of trainee nurses in Sri Lanka

27

Colonization with selected antibiotic resistant bacteria among a cohort of Sri Lankan university students

28

Retrospective Economic Evaluation of Off-Label Dalbavancin Use in an Acute Medical Hospital

29

Evaluation of non-medical prescriber interventions in the management of gram-negative bacteraemia

30

A miniaturised method for measuring inhibition of bacterial growth

31

UTI treatment of elderly patients at Kettering General Hospital

32

Evaluation of the effect of different sugars and polyols on Streptococcus mutans biofilm

33

A feasibility study to investigate the effects of procalcitonin testing on antibiotic prescribing in lower respiratory tract infections in an Irish hospital

35

A means to an end – Adaptation to antibiotics related to biofilm formation in Critical Care Medicine, with relation to Pseudomona aeruginosa

36

ADMISSION SCREENING AND ISOLATION OF PATIENTS COLONISED WITH CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE AN AUDIT OF LOCAL PRACTICE

38

Influenza vaccination and infection in long-stay hospital patients – an antimicrobial stewardship opportunity

39

PBP inhibitors discovered using a modified phage display platform (Bicycles®)

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